NAFDI NEWS
Volume 26  Fall 1999


Ask the Doctor
Kathleen T. Brady, M.D., Professor of Psychiatry, Medical University of South Carolina

Is it actually true that taking drugs can help me with my substance abuse problem?

Yes, certain licit ‘drugs' can help you with substance abuse problems. There are, basically, three types of medication that can do this; those where the licit drug will cause nausea or other unpleasant side effects if you take the substance after taking the helpful drug; those that have no effect on their own, but block the effect of the abused substance, so it is no longer reinforcing; and drugs that treat mood and anxiety symptoms in those individuals for which these problems lead to taking substances to  relieve psychiatric symptoms.

As the ‘good drugs' are not habit forming, after the substance habit is discontinued and broken with the assistance of these prescribed drugs, it's no problem to stop taking the helpful drugs and become substance free and in ‘control' of yourself once again.

I've read about a medication called Naltrexone; can this help me with my substance/alcohol abuse problems?

A number of well-controlled, scientifically valid studies indicate that Naltrexone can be helpful in relapse prevention in alcohol use disorders. These studies indicate that nalxetrone acts by decreasing craving for alcohol but may also diminish the positively reinforcing effects of alcohol if alcohol is ingested after Naltrexone administration. All of the studies with Naltrexone were conducted in conjunction with some type of psychosocial therapy. As such, it is likely that the most effective treatment for alcoholism will include both counseling and medications.

Naltrexone received FDA approval for the treatment of alcohol dependence in 1996. It was the first drug approved to treat alcoholism in many years. Of interest, Naltrexone acts to block the opiate receptor and had been used for many years to treat opiate dependence. Naltrexone use has been, generally, more successful in the treatment of alcoholism than in the treatment of opiate dependence.



copyright 1999, The National Foundation for Depressive Illness, Inc.
Reproduction is permitted, with proper reference to source.